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In 2008, shortly after delivering her first daughter, Karen was in a life threatening car accident, forcing her to be on complete bed rest. When the realization hit, she was not only grateful to be alive but in a different state of mind. Without physical activity her body and mind morphed. No longer petite-sized she accepted the changes and sought a new wardrobe.

She identified a need and had the desire to create clothes that would benefit, inspire and empower women and their changing bodies. Karen's contemporary ready-to-wear outfits truly fit and compliment all women. Karen creates stylish yet effortless clothing with various women's shapes in mind. Her collection is sophisticated yet feminine and always with a twist that has just the right blend of fashion and comfort.

Designed and created in San Francisco, CA, U by Karen Klein is available exclusively for online purchase. In addition to the U collection, the website features additional designers and accessories, hand picked by Karen Klein, completing the perfect ensemble. The website provides a place where women can learn new styling tips and gather fashion ideas from videos, photos, and an interactive interface all designed to make U feel more confident and beautiful.